The best calming supplements for dogs and cats in 2025 are helping pet parents everywhere manage stress, anxiety, and overactive behaviors the natural way. Whether your furry friend struggles with separation anxiety, loud noises, travel stress, or general nervousness, the right natural pet anxiety relief product can make a huge difference in their everyday comfort.
This year’s top picks include everything from gentle probiotic blends to soft chews and hemp calming supplements for pets—all vetted, highly reviewed, and trusted by pet parents. Every product below is safe for most dogs and cats, easy to use, and created to support a calmer, happier life for your four-legged family member.
Disclaimer:
As an Amazon affiliate I earn a small commission at no extra cost to you. Thank you for supporting my small business.
Looking for tasty rewards that keep your dog focused? Visit my Best Training Treats guide for the top picks your pup will love.
Pet Calming Treats Reviews: Expert-Picked Supplements That Really Work
Best Probiotic Calming Supplement
Why We Love It: Includes a probiotic strain (Lactobacillus rhamnosus) clinically shown to reduce pet anxiety and stress-related behaviors.
Best For: Pets with long-term stress or anxious behavior.
Pro: Easy-to-use capsules mixed with food.
Con: Works gradually, not instant relief.
Best Tasty Chews for Dogs & Cats
Why We Love It: Soft chews made with melatonin, chamomile, and valerian root for safe, natural relaxation.
Best For: Separation anxiety, travel, or stressful vet visits.
Pro: Convenient chewable form; pets love the taste.
Con: May require consistent use for full effect.
Pet Calming Treats Reviews: Top-Rated Picks for 2025
Best Peanut Butter Calming Treats
Why We Love It: Made with organic hemp, L-theanine, chamomile, and melatonin to calm anxious dogs.
Best For: Car rides, fireworks, and loud noises.
Pro: Peanut butter flavor dogs love.
Con: Larger dogs may need multiple chews.
Best Hemp-Based Calming Formula
Why We Love It: Combines hemp, melatonin, chamomile, and valerian root for fast-acting stress relief.
Best For: Pets with storm anxiety, travel stress, or general nervousness.
Pro: Available as soft chews or tablets.
Con: Some pets may dislike the tablet form.
Discover BarkBox — monthly toys & treats that keep your dog entertained, happy, and mentally stimulated.
Best Natural Liquid Calming Solution
Why We Love It: 100% organic hemp oil, rich in CBD and natural cannabinoids, helps reduce anxiety, improve sleep, and ease joint pain.
Best For: Multi-pet households (safe for dogs & cats).
Pro: Can be added to food or given directly.
Con: Strong taste may not appeal to all pets.
✅ Conclusion: Which Calming Supplement Is Best?
When it comes to choosing the best calming supplements for dogs and cats in 2025, the right pick depends on your pet’s needs:
-
For probiotics & long-term calm: Purina Pro Plan Calming Care
-
For tasty everyday chews: VetIQ Calming Aid
-
For anxious dogs who love treats: Zesty Paws Calming Bites
-
For hemp + herbal relief: NaturVet Quiet Moments
-
For versatile, natural oil: Pure Organic Hemp Oil
👉 No matter your pet’s personality, there’s a calming supplement to help them live a more relaxed, stress-free life.