The best calming supplements for cats in 2025 can help anxious felines relax without heavy sedation. From loud noises and travel to separation anxiety and household changes, many cats are more stressed than we realize.
In this guide, you’ll find vet‑approved calming products—including chews, oils, probiotics, and pheromone diffusers—plus tips on when to use them and when it is time to talk to your vet.
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🐾 Editor’s Pick: NaturVet Quiet Moments Calming Aid for Cats
This gentle, vet‑approved supplement helps ease cat anxiety with natural ingredients like L‑tryptophan, melatonin, and ginger—ideal for travel, vet visits, and storm season without heavy drowsiness.
This gentle, vet-approved calming supplement helps ease anxiety and stress in cats using natural ingredients like L-tryptophan, melatonin, and ginger. Perfect for travel, vet visits, and storm season — keeping your kitty relaxed without drowsiness.
Reducing anxiety isn’t just about supplements—your cat’s environment plays a big role too. Learn how an automatic litter box for cats can create a calmer, cleaner space for your feline friend.
🏆 1. Purina Pro Plan Veterinary Calming Care
Why We Love It: This probiotic powder contains Lactobacillus rhamnosus, clinically shown to reduce anxious behavior and improve mood in cats. It supports gut health, which is directly linked to emotional balance.
Pros:
Vet-formulated and clinically tested
Easy-to-mix powder — cats won’t notice it
Long-term stress and digestive support
Cons:
Must be used daily for best results
If your cat struggles with stress or litter box anxiety, an automatic litter box can help. Check out my guide to the best automatic litter boxes for cats to create a calmer, cleaner space for your feline friend.
🐾 2. Pet Honesty Calming Chews for Cats
Why We Love It: These tasty chews are made just for cats, combining L-Theanine, Chamomile, and Thiamine to naturally reduce stress and promote calm behavior without sedation. Pet Honesty’s formula is vet-recommended and helps support overall emotional balance and relaxation.
Pros:
Specially formulated for cats
Made with natural, non-sedating ingredients
Helps manage situational anxiety and hyperactivity
Cons:
Slightly chewy texture may not appeal to picky eaters
Best results seen with consistent use over several days
For cats who struggle with appetite due to stress, choosing the right diet can make a big difference. Check out my roundup of the best cat foods recommended by vets to support both nutrition and calm
🌿 3. Vetoquinol FELIWAY Classic Calming Diffuser
Why We Love It: FELIWAY mimics natural feline pheromones to create a sense of comfort and familiarity. It helps reduce stress-related behaviors like hiding, scratching, or marking — all without medication. Ideal for use during household changes, travel, or introductions to new pets.
Pros:
Scientifically proven to help calm cats naturally
Easy plug-in format — no treats or dosing needed
Perfect for long-term anxiety prevention
Cons:
Requires a refill every 30 days
Not suitable for open or drafty rooms
💧 5. Billion Pets Organic Hemp Oil
Why We Love It: This organic hemp oil supports calm behavior, joint mobility, and coat health. Simply add a few drops to your cat’s food or water.
Pros:
Natural and chemical-free
Works for both cats and dogs
Supports joint health and sleep
Cons:
Strong natural flavor may not appeal to picky eaters
Calming your cat is only one part of their wellbeing—keeping them playful is just as important. Explore our best cat toys on Amazon in 2025 to boost exercise and mental health.
🐱Which Calming Supplement Is Best for Cats?
Every cat is unique, but the goal is the same—to reduce anxiety and restore peace naturally. The top‑rated calming treats for cats in 2025 have been carefully selected for safety, effectiveness, and vet approval, helping your furry friend live a calmer, happier life.